Hormesis: A Conversation with a Critic
نویسنده
چکیده
OBJECTIVE In this commentary I respond to points raised in the commentary by Mushak [Ad hoc and fast forward: the science and control of hormesis growth and development. Environ Health Perspect 117:1333-1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology. DISCUSSION In this commentary I demonstrate that Mushak's analysis contains critical statistical errors and misunderstandings of statistical concepts that invalidate its conclusions concerning the frequency of hormesis in the toxicologic literature. CONCLUSIONS In his commentary Mushak offers no significant new conceptual insights, and his key technical criticisms of hormesis frequency findings are unfounded.
منابع مشابه
Look Different: Effect of Radiation Hormesis on the Survival Rate of Immunosuppressed Mice
Background: Hormesis is defined as the bio-positive response of something which is bio-negative in high doses. In the present study, the effect of radiation hormesis was evaluated on the survival rate of immunosuppressed BALB/c mice by Cyclosporine A.Materials and Methods: We used 75 consanguine, male, BALB/c mice in this experiment. The first group received Technetium-99m (3700Bq) and the seco...
متن کاملRadiation hormesis and adoptive response induced by low doses of limiting radiation
Ionizing radiation has long been known to produce detrimental biological effects. Although these harmful effects are the results of high doses of exposure, some other maladies such as mutation and cancer seems to be induced at low doses of exposure. In recent decades, however, some pioneer scientists have indicated that ionizing radiation like many other essential agents has toxic effects ...
متن کاملVocabulary Lists for EAP and Conversation Students
Despite the abundance of research investigating general and academic vocabularies and developing dozens of word lists, few studies have compared academic vocabulary with general service word lists such as conversation vocabulary. Many EAP researchers assume that university students need to know all the words in West’s (1953) General Service List (GSL) as a prerequisite to academic words (e.g., ...
متن کاملAd hoc and Fast Forward: The Science of Hormesis Growth and Development
BACKGROUND Hormesis is a binary response phenomenon with low-dose stimulation (or inhibition) of effects by substances producing opposite high-dose responses. Hormesis, after decades of obscurity, has undergone a renaissance in recent years, with rapid growth benefiting greatly from the systematized efforts of such proponents as the hormesis group at the University of Massachusetts-Amherst led ...
متن کاملA perspective on the scientific, philosophical, and policy dimensions of hormesis.
The hormesis concept has broad implications for biology and the biomedical sciences. This perspective on hormesis concentrates on toxicology and toxicological risk assessment and secondarily explores observations from other fields. It considers the varied manifestations of hormesis in the context of a broad family of biological stress responses. Evidence for hormesis is reviewed, and the hormes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 117 شماره
صفحات -
تاریخ انتشار 2009